(2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid

Base Information

• Chemical Name: (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid
• CAS No.: 151295-14-6
• Molecular Formula: C₁₄H₈ClF₂NO₄S
• Molecular Weight: 359.738

Synonyms:(2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid

Chemical Property of (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid

Chemical Property:

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Technology Process of (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid

There total 2 articles about (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

α-bromo-(3-fluorophenyl)acetic acid (24805-50-3) + 2-chloro-3-fluoro-6-nitrobenzene-1-thiol → (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid (151295-14-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 2h; Heating;

DOI:10.1021/jm00074a028

Reference yield:

(3-fluorophenyl)acetic acid (331-25-9) → (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid (151295-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Br₂ / CCl₄ / 2 h / Heating; Irradiation

2: 98 percent / 1.) NaOH / H₂O; ethanol / 2 h / Heating

With sodium hydroxide; bromine; In tetrachloromethane; ethanol; water;

DOI:10.1021/jm00074a028

Reference yield: 76.0%

(2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid (151295-14-6) → 8-Chloro-7-fluoro-2-(3-fluoro-phenyl)-4H-benzo[1,4]thiazin-3-one (151295-17-9)

Guidance literature:

With ammonium hydroxide; iron(II) sulfate; In water; 1.) 2 h, RT, 2.) 15 min, 50 deg C;

DOI:10.1021/jm00074a028

upstream raw materials:

α-bromo-(3-fluorophenyl)acetic acid

(3-fluorophenyl)acetic acid

Downstream raw materials:

8-Chloro-7-fluoro-2-(3-fluoro-phenyl)-4H-benzo[1,4]thiazin-3-one

8-Chloro-7-fluoro-2-(3-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

9-Chloro-8-fluoro-2-(3-fluoro-phenyl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid ethyl ester

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