1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

Base Information

Chemical Name:1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone
CAS No.:1028313-77-0
Molecular Formula:C₃₄H₄₂F₂N₂O₃Si
Molecular Weight:592.801
Hs Code.:

1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-propenone

Synonyms:1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

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Chemical Property of 1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

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Technology Process of 1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

There total 5 articles about 1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14755-02-3,588-30-7
3-hydroxy-trans-cinnamic acid

: 1028313-77-0
1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 0 - 20 °C

3: aq. NaHCO₃ / CHCl₃ / 0.17 h

With 1H-imidazole; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; chloroform; N,N-dimethyl-formamide; 1: silylation / 2: Chlorination / 3: Acylation;
DOI:10.1021/jm990291q

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 1028313-77-0
1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / K₂CO₃ / toluene / 12 h / Heating

2: aq. NaHCO₃ / CHCl₃ / 0.17 h

With sodium hydrogencarbonate; potassium carbonate; In chloroform; toluene; 1: Alkylation / 2: Acylation;
DOI:10.1021/jm990291q

Reference yield:

: 365-24-2
4,4'-difluorobenzhydryl alcohol

: 1028313-77-0
1-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / toluene / Heating

2: 69 percent / K₂CO₃ / toluene / 12 h / Heating

3: aq. NaHCO₃ / CHCl₃ / 0.17 h

With sulfuric acid; sodium hydrogencarbonate; potassium carbonate; In chloroform; toluene; 1: Condensation / 2: Alkylation / 3: Acylation;
DOI:10.1021/jm990291q