3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester

Base Information

• Chemical Name: 3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester
• CAS No.: 148227-91-2
• Molecular Formula: C₂₅H₃₄N₂O₂
• Molecular Weight: 394.557
• Mol file: 148227-91-2.mol

Synonyms:3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester

Chemical Property of 3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester

There total 1 articles about 3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,3-dimethylbutanoic acid chloride (7065-46-5) + 1,4-dibenzyl-2-hydroxypiperazine (94437-04-4,148228-25-5,148228-26-6) → 3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester (148227-91-2)

Guidance literature:

With triethylamine; In benzene; Ambient temperature;

DOI:10.1021/jm00060a006

Reference yield:

3,3-Dimethyl-butyric acid 1,4-dibenzyl-piperazin-2-ylmethyl ester (148227-91-2) → 3,3-Dimethyl-butyric acid 1,4-bis-(3,4,5-trimethoxy-benzoyl)-piperazin-2-ylmethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, conc. HCl / 10percent Pd/C / ethanol / 40 °C / 2068.6 Torr

2: 69 percent / Et₃N / benzene / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1021/jm00060a006

upstream raw materials:

3,3-dimethylbutanoic acid chloride

1,4-dibenzyl-2-hydroxypiperazine