2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

Base Information

Chemical Name:2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid
CAS No.:1372540-58-3
Molecular Formula:C₂₁H₂₃N₃O₃
Molecular Weight:365.432
Hs Code.:

Synonyms:2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

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Chemical Property of 2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

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Technology Process of 2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

There total 5 articles about 2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅N₃O₃

: 1372540-58-3
2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

Guidance literature:: C₂₂H₂₅N₃O₃; With lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 2h;

With hydrogenchloride; In water;

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1372540-58-3
2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate; N-methoxylamine hydrochloride / copper diacetate / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

1.2: pH 1

2.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

4.1: iron / 5 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6.1: lithium hydroxide / tetrahydrofuran / 2 h / 50 °C

With potassium tert-butylate; N-methoxylamine hydrochloride; iron; potassium carbonate; triethylamine; HATU; lithium hydroxide; copper diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 193481-78-6
3-Amino-5-chloro-2-nitrobenzoic acid

: 1372540-58-3
2-methyl-1-[(2-methylphenyl)methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

3: iron / 5 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5: lithium hydroxide / tetrahydrofuran / 2 h / 50 °C

With iron; potassium carbonate; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;