N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide

Base Information

• Chemical Name: N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide
• CAS No.: 223511-24-8
• Molecular Formula: C₂₁H₂₇N₃O₂
• Molecular Weight: 353.464
• Mol file: 223511-24-8.mol

Synonyms:N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide

Chemical Property of N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide

There total 6 articles about N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methoxyphenyl)piperazine (38212-30-5) + N-(4-chloromethyl-benzyl)-acetamide (223512-41-2) → N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide (223511-24-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/S0960-894X(00)00128-1

Reference yield:

4-(4-methoxyphenyl)piperazine (38212-30-5) → N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide (223511-24-8)

Guidance literature:

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → N-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)phenylmethyl)acetamide (223511-24-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / aq. NaOH / 20 °C

2: 72 percent / H₂SO₄ / Heating

3: 98 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

4: 91 percent / SOCl₂ / CHCl₃ / Heating

5: K₂CO₃ / dimethylformamide / 80 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1: Acetylation / 2: Esterification / 3: Reduction / 4: Chlorination / 5: Alkylation;

DOI:10.1016/S0960-894X(00)00128-1

upstream raw materials:

4-(4-methoxyphenyl)piperazine

N-(4-chloromethyl-benzyl)-acetamide

p-aminomethylbenzoic acid

4-[(Acetylamino)methyl]-benzoic acid