4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

Base Information

Chemical Name:4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline
CAS No.:1379615-61-8
Molecular Formula:C₂₁H₁₅ClF₃N₃O
Molecular Weight:417.818
Hs Code.:

Synonyms:4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

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Chemical Property of 4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

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Technology Process of 4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

There total 10 articles about 4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1379615-55-0
2-bromo‐4-chloro‐3-methylquinoline

: 1379615-57-2
4-(4,4,5,5-tetramethyl‐1,3,2-dioxaborolan‐2-yl)-1‐(4-(trifluoromethoxy)benzyl)‐1H‐pyrazole

: 1379615-61-8
4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00371

Reference yield: 38.0%

: 1379615-61-8
4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

Guidance literature:

Reference yield:

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1379615-61-8
4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 90 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00371