N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

Base Information

Chemical Name:N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine
CAS No.:1476076-17-1
Molecular Formula:C₂₄H₃₀N₆O
Molecular Weight:418.542
Hs Code.:

Synonyms:N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

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Chemical Property of N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

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Technology Process of N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

There total 6 articles about N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 918524-63-7
1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

: 1476076-16-0
6-chloro-N-(2-(2-methoxyphenyl)propyl)pyrimidin-4-amine

: 1476076-17-1
N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; sodium carbonate; In isopropyl alcohol; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

: 81616-80-0,81616-81-1,91061-46-0,96687-71-7
(S)-2(2-methoxyphenyl)propionic acid

: 1476076-17-1
N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.1: triphenylphosphine / 0.25 h / 20 °C

2.2: 18 h

3.1: hydrazine / methanol / 18 h

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h

5.1: sodium carbonate; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate / isopropyl alcohol / 4 h / 90 °C / Inert atmosphere

With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; lithium aluminium tetrahydride; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; In tetrahydrofuran; methanol; isopropyl alcohol;

Reference yield:

: 188053-29-4
2-(ortho-methoxyphenyl)propan-1-amine

: 1476076-17-1
N-(2-(2-methoxyphenyl)propyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h

2: sodium carbonate; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate / isopropyl alcohol / 4 h / 90 °C / Inert atmosphere

With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;