1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one

Base Information

• Chemical Name: 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one
• CAS No.: 1197421-93-4
• Molecular Formula: C₁₇H₂₁NO₅
• Molecular Weight: 319.357

Synonyms:1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one

Chemical Property of 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one

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Technology Process of 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one

There total 1 articles about 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one (1197422-23-3) → 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one (1197421-93-4)

Guidance literature:

With hydrogenchloride; acetic acid; In water; acetonitrile; at -5 - 0 ℃; for 3.5h;

DOI:10.1021/jm9008532

Reference yield: 88.0%

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one (1197421-93-4) + hydrocinnamic acid chloride (645-45-4) → 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(3-phenylpropanoyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one (1197421-97-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jm9008532

Reference yield: 77.0%

(4-biphenylyl)acetic acid (5728-52-9) + 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-hydroxyethyl]-4-(acetoxy)-azetidin-2-one (1197421-93-4) → 1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(biphenyl-4-ylacetyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one (1197421-99-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jm9008532

upstream raw materials:

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one

Downstream raw materials:

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(biphenyl-4-ylacetyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(4-phenylbutanoyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one

1-(4-phenylbutanoyl)-(3R,4R)-3-[1(R)-(3-phenylpropanoyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one

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