toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester
• CAS No.: 1360599-76-3
• Molecular Formula: C₂₀H₂₀ClN₃O₅S
• Molecular Weight: 449.915
• Mol file: 1360599-76-3.mol

Synonyms:toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property of toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

There total 4 articles about toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

(+/-)-2,3-dihydroxypropyl tosylate (51704-66-6) + 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (58905-19-4) → toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester (1360599-76-3)

Guidance literature:

With trifluorormethanesulfonic acid; In toluene; at 20 ℃; for 71h; Inert atmosphere;

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester (1360599-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetone / 1.5 h / 0 - 20 °C

2: trifluorormethanesulfonic acid / 60 h / 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; triethylamine; In acetone;

DOI:10.1016/j.bmc.2013.03.006

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester (1360599-76-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 1.5 h / Inert atmosphere; Cooling with ice

2: hydrogenchloride; water / methanol / Reflux

3: trifluorormethanesulfonic acid / 60 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; trifluorormethanesulfonic acid; water; In methanol;

DOI:10.1016/j.bmc.2013.03.006

upstream raw materials:

p-toluenesulfonyl chloride

solketal tosylate

(+/-)-2,3-dihydroxypropyl tosylate

1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Downstream raw materials:

1-[2-(4-chlorophenyl)-4-(2-propoxyphenoxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole

1-[[4-[(2-allyloxyphenoxy)methyl]-2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole

1-[4-(2-butoxyphenoxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole

1-[[4-[(2-(3-butenyloxy)phenoxy)methyl]-2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole