methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

Base Information

Chemical Name:methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate
CAS No.:1389326-35-5
Molecular Formula:C₂₂H₂₂ClFN₂O₄
Molecular Weight:432.879
Hs Code.:

Synonyms:methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

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Chemical Property of methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

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Technology Process of methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

There total 7 articles about methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1389326-34-4
methyl 2-(4-amino-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

: 1389326-35-5
methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

Guidance literature:: In tert-butyl alcohol; at 50 ℃; for 10h;

Reference yield:

: 102735-88-6
5-fluoro-2-methyl-1,3-dinitrobenzene

: 1389326-35-5
methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 5 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

3.1: sodium hydroxide / 3 h / 60 °C

4.1: tert-butyl alcohol / 16 h / 50 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

5.2: 20 °C

6.1: sulfuric acid / 2 h / 50 °C

7.1: tert-butyl alcohol / 10 h / 50 °C

With n-butyllithium; sulfuric acid; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 446-10-6
2-nitro-4-fluorotoluene

: 1389326-35-5
methyl 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / 6 h / -5 - 20 °C

2.1: N,N-dimethyl-formamide / 5 h / 120 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4.1: sodium hydroxide / 3 h / 60 °C

5.1: tert-butyl alcohol / 16 h / 50 °C

6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

6.2: 20 °C

7.1: sulfuric acid / 2 h / 50 °C

8.1: tert-butyl alcohol / 10 h / 50 °C

With n-butyllithium; sulfuric acid; hydrogen; nitric acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;