(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Base Information

Chemical Name:(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol
CAS No.:639006-77-2
Molecular Formula:C₃₃H₄₆O₅Si
Molecular Weight:550.811
Hs Code.:

Synonyms:(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Suppliers and Price of (2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

There total 3 articles about (2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 639006-75-0
(2S,4S,5R,6R)-7-tert-butyldiphenylsilyloxy-5-hydroxy-2-(p-methoxybenzyloxy)-4,6-dimethyl-3-heptanone

: 639006-77-2
(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

: (2R,3R,4S,5R,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at -40 - 0 ℃;
DOI:10.1021/ol035874f

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 639006-77-2
(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ti(i-PrO)4; TiCl₄; i-Pr₂NEt / CH₂Cl₂ / 1.5 h / -78 °C

1.2: 82 percent / CH₂Cl₂ / 2 h / -78 °C

2.1: 92 percent / (Me₄N)HB(OAc)3 / acetonitrile; acetic acid / -40 - 0 °C

With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/ol035874f

Reference yield:

: 312538-65-1
(S)-2-p-Methoxybenzyloxy-3-pentanone

: 639006-77-2
(2R,3R,4S,5S,6S)-1-tert-butyldiphenylsilyloxy-6-(4-methoxybenzyloxy)-2,4-dimethyl-3,5-heptanediol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ti(i-PrO)4; TiCl₄; i-Pr₂NEt / CH₂Cl₂ / 1.5 h / -78 °C

1.2: 82 percent / CH₂Cl₂ / 2 h / -78 °C

2.1: 92 percent / (Me₄N)HB(OAc)3 / acetonitrile; acetic acid / -40 - 0 °C

With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/ol035874f