3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

Base Information

Chemical Name:3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester
CAS No.:365455-36-3
Molecular Formula:C₇₂H₉₁N₃O₁₅Si
Molecular Weight:1266.61
Hs Code.:

3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-<i>tert</i>-butoxycarbonylamino-propionic acid <i>tert</i>-butyl ester

Synonyms:3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

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Chemical Property of 3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

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Technology Process of 3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

There total 12 articles about 3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71630-31-4,7738-22-9
N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester

: 365455-36-3
3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 13 percent / potassium tert-butoxide / toluene; tetrahydrofuran / 1.5 h

2: 97 percent / tetrabutylammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

3: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

4: 0.98 g / pyridine / 12 h

5: 0.92 g / sodium methoxide / methanol / 0.67 h

6: 70 percent / potassium tert-butoxide / toluene / 18 h / 20 °C

7: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

8: 0.108 g / pyridine / 12 h

With pyridine; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; acetic acid; platinized Raney nickel T₄; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jo061670b

Reference yield:

: 365455-26-1
O-(3,4-di-O-benzyl-2-deoxy-2-nitro-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester

: 365455-36-3
3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

2: 0.98 g / pyridine / 12 h

3: 0.92 g / sodium methoxide / methanol / 0.67 h

4: 70 percent / potassium tert-butoxide / toluene / 18 h / 20 °C

5: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

6: 0.108 g / pyridine / 12 h

With pyridine; potassium tert-butylate; hydrogen; sodium methylate; platinized Raney nickel T₄; In methanol; ethanol; toluene;
DOI:10.1021/jo061670b

Reference yield:

: 365455-28-3
O-(3,4-di-O-benzyl-6-O-tert-butyldiphenylsilyl-2-deoxy-2-nitro-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester

: 365455-36-3
3-{3-acetylamino-6-[3-acetylamino-4,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy}-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / tetrabutylammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

3: 0.98 g / pyridine / 12 h

4: 0.92 g / sodium methoxide / methanol / 0.67 h

5: 70 percent / potassium tert-butoxide / toluene / 18 h / 20 °C

6: H₂ / platinized Raney nickel T₄ / ethanol / 12 h / 3878.71 Torr

7: 0.108 g / pyridine / 12 h

With pyridine; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; acetic acid; platinized Raney nickel T₄; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jo061670b