4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide

Base Information

• Chemical Name: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide
• CAS No.: 1581700-94-8
• Molecular Formula: C₂₁H₂₃F₃N₄O₃
• Molecular Weight: 436.434
• Mol file: 1581700-94-8.mol

Synonyms:4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide

Chemical Property of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide

There total 6 articles about 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (694499-26-8) + 4-methyl-3-nitrobenzoic acid (96-98-0) → 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide (1581700-94-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2017.03.064

Reference yield:

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (694499-26-8) + 4-methyl-3-nitrobenzoyl chloride (10397-30-5) → 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide (1581700-94-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2017.02.041

Reference yield:

4-methyl-3-nitrobenzoic acid (96-98-0) → 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-nitrobenzamide (1581700-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 5 h / 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2017.02.041

upstream raw materials:

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

4-methyl-3-nitrobenzoic acid

4-methyl-3-nitrobenzoyl chloride

1-methyl-4-nitro-2-(trifluoromethyl) benzene

Downstream raw materials:

2-amino-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide

6-hydroxy-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)nicotinamide

N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-2-(methylamino)pyrimidine-5-carboxamide

2-(ethylamino)-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide