6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione
CAS No.:847995-40-8
Molecular Formula:C₂₅H₂₈N₂O₄
Molecular Weight:420.508
Hs Code.:

6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

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Chemical Property of 6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

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Technology Process of 6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

There total 6 articles about 6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 847995-38-4
benzoic acid 4-{3-[6-(3,5-dimethyl-benzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-propenyl}-phenyl ester

: 847995-40-8
6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

Guidance literature:: With ammonia; In methanol; at 20 ℃;
DOI:10.1021/jm040845b

Reference yield:

: 5339-06-0
4-formylphenyl benzoate

: 847995-40-8
6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. K₂CO₃; tris[2-(2-methoxyethoxy)ethyl]amine / CH₂Cl₂ / 20 °C

1.2: 68 percent / aq. HCl / 20 °C

2.1: 78 percent / KH₂PO₄; NaBH₄ / methanol / 1 h / 0 °C

3.1: 97 percent / diisopropyl ethylamine / CH₂Cl₂ / 0 - 20 °C

4.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.17 h

4.2: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C

5.1: 78 percent / NH₃ / methanol / 20 °C

With sodium tetrahydroborate; potassium dihydrogenphosphate; N,O-bis-(trimethylsilyl)-acetamide; Tris(3,6-dioxaheptyl)amine; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm040845b

Reference yield:

: 20649-40-5
(E)-4-(3-hydroxyprop-1-enyl)phenol

: 847995-40-8
6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 58 percent / aq. NaOH / propan-2-ol / 0.5 h / 20 °C

2.1: 97 percent / diisopropyl ethylamine / CH₂Cl₂ / 0 - 20 °C

3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.17 h

3.2: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C

4.1: 78 percent / NH₃ / methanol / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm040845b