C₂₁H₂₁FN₄O₄

Base Information

• Chemical Name: C₂₁H₂₁FN₄O₄
• CAS No.: 1399119-68-6
• Molecular Formula: C₂₁H₂₁FN₄O₄
• Molecular Weight: 412.421
• Mol file: 1399119-68-6.mol

Synonyms:C₂₁H₂₁FN₄O₄

Chemical Property of C₂₁H₂₁FN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₁FN₄O₄

There total 7 articles about C₂₁H₂₁FN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H23FN4O6 (1399119-67-5) → C21H21FN4O4 (1399119-68-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 0.75h;

Reference yield:

isatoic anhydride (118-48-9) → C21H21FN4O4 (1399119-68-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dmap / N,N-dimethyl-formamide / 4.5 h / 20 °C

2.1: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C / Cooling with ice

3.1: potassium hydroxide / ethanol / 16 h / Reflux

3.2: 20 °C / pH 3 - 4

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

4.2: 3 h / 20 °C / Cooling with ice

5.1: hydrogenchloride / 1,4-dioxane / Reflux

5.2: 3 h / 20 °C / pH > 13

5.3: pH < 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 20 °C

7.1: hydrazine hydrate / ethanol / 0.75 h / 20 °C

With hydrogenchloride; sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; dmap; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

2-fluoro-5-methyl-benzoic acid (321-12-0) → C21H21FN4O4 (1399119-68-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride / 20 h / Reflux

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 6.5 h / Inert atmosphere; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

3.2: 3 h / 20 °C / Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane / Reflux

4.2: 3 h / 20 °C / pH > 13

4.3: pH < 2

5.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 20 °C

6.1: hydrazine hydrate / ethanol / 0.75 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

2-fluoro-5-methyl-benzoic acid

isatoic anhydride

3-tert-butyl-1,2,3,4-tetrahydroquinazoline-2,4-dione

2-fluoro-5-bromomethyl benzoic acid methyl ester