1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

Base Information

Chemical Name:1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
CAS No.:1364720-11-5
Molecular Formula:C₂₄H₂₃BBrF₂N₃
Molecular Weight:482.179
Hs Code.:

Synonyms:1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

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Chemical Property of 1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

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Technology Process of 1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

There total 4 articles about 1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-89-4
piperidine

: 1364719-57-2
1,3-dimethyl-2,5,6-tribromo-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

: 536-74-3
phenylacetylene

: 1364720-11-5
1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In benzene; at 60 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c2ob07004a

Reference yield:

: 154793-49-4
5,5-difluoro-1,3-dimethyl-5H-4λ4,5λ,4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine

: 1364720-11-5
1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 2 steps

1: benzyltriethylammonium tribromide / dichloromethane / 0 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / benzene / 6 h / 60 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; benzyltriethylammonium tribromide; In dichloromethane; benzene; 2: Sonogashira coupling;
DOI:10.1039/c2ob07004a

Reference yield:

: 1364719-49-2
1,3-dimethyl-2,5-dibromo-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

: 1364720-11-5
1,3-dimethyl-2-bromo-5-(piperidin-1-yl)-6-(phenylethynyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane

2: CuI; Pd(P(C₆H₅)3)4; N(CH₂CH₃)3 / benzene

With CuI; Pd(P(C₆H₅)3)4; N(CH₂CH₃)3; In dichloromethane; benzene;
DOI:10.1039/c2ob07004a