4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI)

Base Information

• Chemical Name: 4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI)
• CAS No.: 184719-44-6
• Molecular Formula: C₇H₆O₄
• Molecular Weight: 154.122
• Mol file: 184719-44-6.mol

Synonyms:4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI)

Chemical Property of 4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI)

Chemical Property:

• PSA: 56.51000
• LogP: 0.42640

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-oxo-4H-pyran-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI)

There total 3 articles about 4H-Pyran-3-carboxylicacid,4-oxo-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Ethoxy-4-oxo-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester (184719-42-4) → 4-Oxo-4H-pyran-3-carboxylic acid methyl ester (184719-44-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h; Yield given; Ambient temperature;

DOI:10.1055/s-1998-5933

Reference yield:

Methyl diformylacetate (64516-46-7) → 4-Oxo-4H-pyran-3-carboxylic acid methyl ester (184719-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 120 h / Ambient temperature

2: PDC, glac. AcOH, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / Ambient temperature

3: TFA / CH₂Cl₂ / 1 h / Ambient temperature

With dipyridinium dichromate; 4 A molecular sieve; acetic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-1998-5933

Reference yield:

6-Ethoxy-4-hydroxy-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester (184719-40-2) → 4-Oxo-4H-pyran-3-carboxylic acid methyl ester (184719-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: PDC, glac. AcOH, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / Ambient temperature

2: TFA / CH₂Cl₂ / 1 h / Ambient temperature

With dipyridinium dichromate; 4 A molecular sieve; acetic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-1998-5933

upstream raw materials:

6-Ethoxy-4-oxo-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester

Methyl diformylacetate

6-Ethoxy-4-hydroxy-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester