1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene

Base Information

• Chemical Name: 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene
• CAS No.: 1026632-86-9
• Molecular Formula: C₁₃H₁₃F₃O₂S
• Molecular Weight: 290.306
• Mol file: 1026632-86-9.mol

Synonyms:1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene

Chemical Property of 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene

Chemical Property:

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Technology Process of 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene

There total 1 articles about 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 4-tert-Butylphenylacetylene (772-38-3) → 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene (1026632-86-9)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) ether, hexane, -78 deg C, 1 h, 2.) ether, hexane, from -78 deg C, 1 h to RT, 1 h;

Reference yield: 80.0%

N-fluoro-4-methyl-N-octylbenzenesulfonamide + 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene (1026632-86-9) → N-(4-((4-(tert-butyl)phenyl)ethynyl)octyl)-4-methylbenzenesulfonamide

Guidance literature:

With Bathocuproine; copper(II) bis(trifluoromethanesulfonate); lithium tert-butoxide; In ethyl acetate; at 80 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201900992

Reference yield: 78.0%

Cyclohexyl isocyanide (931-53-3) + 1-(tert-butyl)-4-{[(trifluoromethyl)sulfonyl]ethynyl}benzene (1026632-86-9) → (E)-N-{4-[4-(tert-butyl)phenyl]-1,1,1-trifluorobut-3-yn-2-ylidene}cyclohexanamine

Guidance literature:

With copper diacetate; In acetonitrile; at 0 - 15 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00730

upstream raw materials:

trifluoromethylsulfonic anhydride

4-tert-Butylphenylacetylene