2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

Base Information

Chemical Name:2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine
CAS No.:1613136-72-3
Molecular Formula:C₂₁H₂₇NO
Molecular Weight:309.451
Hs Code.:

Synonyms:2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

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Chemical Property of 2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

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Technology Process of 2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

There total 4 articles about 2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1613136-58-5
7-amino-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

: cis-2-methoxy-7-[N-(3-phenylpropyl)amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

: trans-2-methoxy-7-[N-(3-phenylpropyl)amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

: trans-7-[N,N-bis(3-phenylpropyl)amino]-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

: 1613136-72-3
2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

Guidance literature:: 3-phenyl-propionaldehyde; 7-amino-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol; With lithium borohydride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/cmdc.201300547

Reference yield:

: 1613136-50-7
N-(2-methoxy-5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)acetamide

: 1613136-72-3
2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 16 h / 95 °C

2.1: lithium borohydride / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium borohydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201300547

Reference yield:

: 1613136-48-3
3-acetamido-5-(3-methoxyphenyl)pentanoic acid

: 1613136-72-3
2-methoxy-N-(3-phenylpropyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentoxide; methanesulfonic acid / dichloromethane / 2.5 h / -10 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 16 h / 95 °C

3.1: lithium borohydride / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: lithium borohydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; methanesulfonic acid; phosphorus pentoxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201300547