methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Base Information

Chemical Name:methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate
CAS No.:365218-54-8
Molecular Formula:C₂₄H₃₈O₅Si
Molecular Weight:434.648
Hs Code.:

Synonyms:methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Suppliers and Price of methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

There total 4 articles about methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 2-((2R,4R,6R)-6-Allyl-4-hydroxy-tetrahydro-pyran-2-ylmethyl)-6-methoxy-benzoic acid methyl ester

: 365218-54-8
methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(01)01038-3

Reference yield:

: 529488-12-8
methyl 2-{(2R,4S)-4-[tert-butyl(diphenyl)silyloxy]-6-methoxytetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

: 365218-54-8
methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl triflate / acetonitrile / 0.75 h / -20 - 0 °C

1.2: TBAF / tetrahydrofuran; H₂O / 16 h / 20 °C

2.1: 89 mg / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; acetonitrile;
DOI:10.1039/b209637b

Reference yield:

: 2-Methoxy-6-((2R,4S)-6-methoxy-4-triisopropylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-benzoic acid methyl ester

: 365218-54-8
methyl 2-{(2R,4R,6S)-6-allyl-4-[tert-butyl(dimethyl)silyloxy]-tetrahydro-2H-pyran-2-ylmethyl}-6-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: TMSOTf / acetonitrile / -78 °C

2: TBAF / tetrahydrofuran / 16 h

3: 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(01)01038-3