2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine

Base Information

• Chemical Name: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine
• CAS No.: 86702-73-0
• Molecular Formula: C₃₆H₃₉N₅O₇
• Molecular Weight: 653.735
• Mol file: 86702-73-0.mol

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine

Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine

There total 3 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-O⁶-methylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-N2-isobutyryl-O6-methylguanosine (82921-45-7) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-O6-methylguanosine (86702-73-0)

Guidance literature:

In pyridine; at 20 ℃;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield:

2'-deoxy-N2-isobutyrylguanosine 3',5'-diisobutyrate (82921-42-4) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-O6-methylguanosine (86702-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: PPh₃; diethyl diazenedicarboxylate / dioxane / 24 h

2: NaOMe / methanol / 1 h / 20 °C

3: 93 percent / pyridine / 20 °C

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; pyridine; methanol; 1: Alkylation / 2: Deacylation / 3: Tritylation;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield:

Isobutyric acid (2R,3S,5R)-5-(2-isobutyrylamino-6-methoxy-purin-9-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-O6-methylguanosine (86702-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol / 1 h / 20 °C

2: 93 percent / pyridine / 20 °C

With sodium methylate; In pyridine; methanol; 1: Deacylation / 2: Tritylation;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-N²-isobutyryl-O⁶-methylguanosine

2'-deoxy-N²-isobutyrylguanosine 3',5'-diisobutyrate