Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz

Base Information

• Chemical Name: Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz
• CAS No.: 275378-59-1
• Molecular Formula: C₃₈H₅₁N₇O₉S₂
• Molecular Weight: 813.996
• Mol file: 275378-59-1.mol

Synonyms:Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz

Chemical Property of Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz

There total 4 articles about Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz-OH*TFA → Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz (275378-59-1)

Guidance literature:

With diphenyl-phosphinic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 72h; Yield given;

DOI:10.1016/S0040-4039(96)02099-0

Reference yield:

Boc-(R)-Phe-(S)-aThr-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser-(S)-Val-Thz-OH → Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz (275378-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N; DMAP / dimethylformamide / 2 h / 20 °C

2: CH₂Cl₂ / 1 h / 0 °C

3: iPr₂NEt; diphenylphosphorazide / dimethylformamide / 73.5 h / 0 - 20 °C

With dmap; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Substitution / 3: Acylation;

DOI:10.1039/a909363j

Reference yield:

Boc-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz-OH → Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(S)-Val-Thz (275378-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 0 °C

2: iPr₂NEt; diphenylphosphorazide / dimethylformamide / 73.5 h / 0 - 20 °C

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Acylation;

DOI:10.1039/a909363j

upstream raw materials:

Boc-(R)-Phe-(S)-aThr-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser-(S)-Val-Thz-OMe

Downstream raw materials:

Cyclo-(R)-Phe-(S)-aThr-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser-(S)-Val-Thz