3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Base Information

• Chemical Name: 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• CAS No.: 1408000-29-2
• Molecular Formula: C₂₁H₂₃F₃N₆O
• Molecular Weight: 432.448
• Mol file: 1408000-29-2.mol

Synonyms:3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Chemical Property of 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

There total 2 articles about 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (694499-26-8) + methyl 3-azido-4-methylbenzoate (855304-57-3) → 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (1408000-29-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -20 - 20 ℃; for 9h;

DOI:10.1021/jm301188x

Reference yield:

3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (1408000-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite; sodium azide / water / 2.16 h / -5 - 20 °C

2: potassium tert-butylate / tetrahydrofuran / 9 h / -20 - 20 °C

With hydrogenchloride; sodium azide; potassium tert-butylate; sodium nitrite; In tetrahydrofuran; water;

DOI:10.1021/jm301188x

Reference yield: 69.0%

3-ethynyl-imidazo[1,2-b]pyridazine (943320-61-4) + 3-azido-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (1408000-29-2) → C29H28F3N9O (1407999-83-0)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 90 ℃;

DOI:10.1021/jm301188x

upstream raw materials:

3-amino-4-methyl benzoic acid methyl ester

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

methyl 3-azido-4-methylbenzoate

Downstream raw materials:

C₂₇H₂₈F₃N₉O

C₂₈H₃₀F₃N₉O

C₂₉H₃₂F₃N₉O

C₃₀H₃₂F₃N₉O