(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Chemical Name:(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate
CAS No.:1380299-27-3
Molecular Formula:C₂₇H₂₀F₃NO₆S
Molecular Weight:543.52
Hs Code.:

Synonyms:(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Chemical Property of (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Technology Process of (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

There total 2 articles about (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 864365-18-4
(4R)-2-(3-(trifluoromethyl)benzyl)-4,5-dihydrothiazole-4-carboxylic acid methyl ester

: 1380299-25-1
C₁₈H₁₆O₈

: 1380299-27-3
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In 1,2-dichloro-ethane; at 120 ℃; for 0.0388889h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/chem.201103936

Reference yield:

: 62935-72-2
2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid

: 1380299-27-3
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.04 h / 120 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103936

Reference yield: 58.0%

: 1380299-27-3
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

: 1380299-30-8
(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; Inert atmosphere;
DOI:10.1002/chem.201103936