2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

Base Information

Chemical Name:2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine
CAS No.:380426-09-5
Molecular Formula:C₂₂H₂₅ClF₂N₆
Molecular Weight:446.931
Hs Code.:

Synonyms:2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

Chemical Property:

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Technology Process of 2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

There total 6 articles about 2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 380426-09-5
2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃; KI / various solvent(s) / 5 h / 100 °C

2: PhI(CF₃CO₂)2 / acetonitrile; H₂O / 65 °C

3: ethanol / Heating

With caesium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; potassium iodide; In ethanol; water; acetonitrile; 2: Hoffmann rearrangement;
DOI:10.1081/NCN-100002493

Reference yield:

: 96-41-3
Cyclopentanol

: 380426-09-5
2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / PPh₃; DEAD / tetrahydrofuran / 0 - 20 °C

2: ethanol / Heating

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;
DOI:10.1081/NCN-100002493

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 380426-09-5
2-chloro-6-[4-[1-(2,6-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / PPh₃; DEAD / tetrahydrofuran / 0 - 20 °C

2: ethanol / Heating

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;
DOI:10.1081/NCN-100002493