3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane

Base Information

• Chemical Name: 3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane
• CAS No.: 1076863-36-9
• Molecular Formula: C₃₉H₅₈N₂O₃
• Molecular Weight: 602.901
• Mol file: 1076863-36-9.mol

Synonyms:3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane

Chemical Property of 3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane

There total 1 articles about 3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

trans-1-cinnamylpiperazine (18903-01-0,114312-65-1,87179-40-6) + Acetic acid (3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-4-ethoxycarbonyloxy-1-methyl-4-oxo-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester → 3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane (1076863-36-9)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2008.07.046

Reference yield: 73.0%

3α-acetoxy-17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholane (1076863-36-9) → 17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholan-3α-ol (1076863-42-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1016/j.bmc.2008.07.046

upstream raw materials:

trans-1-cinnamylpiperazine

Downstream raw materials:

17β-[1-methyl-3-((4-(cinnamyl)piperazin-1-yl)carbonyl)-propyl]etiocholan-3α-ol