4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

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Chemical Name:4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole
CAS No.:919535-12-9
Molecular Formula:C₂₃H₂₅BrN₂O₄
Molecular Weight:473.366
Hs Code.:

Synonyms:4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

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Chemical Property of 4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

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Technology Process of 4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

There total 7 articles about 4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 736137-98-7
4-benzyloxy-3-(tert-butyloxy)carbonyl-5-methoxy-7-oxo-1,2,7,8-tetrahydro-3H,6H-pyrrolo[3,2-e]indole

: 919535-12-9
4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Guidance literature:: With 1H-imidazole; methoxybenzene; phosphorus(V) oxybromide; at 25 ℃; for 25h;
DOI:10.1021/ja064228j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 919535-12-9
4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / tetrahydrofuran / 1.5 h / Heating

2: 72 percent / POBr₃; imidazole; anisole / 25 h / 25 °C

With 1H-imidazole; methoxybenzene; phosphorus(V) oxybromide; In tetrahydrofuran;
DOI:10.1021/ja064228j

Reference yield:

: 736137-96-5
4-benzyloxy-5-methoxy-7-oxo-7,8-dihydro-6H-pyrrolo[3,2-e]indole

: 919535-12-9
4-benzyloxy-7-bromo-3-(tert-butyloxy)carbonyl-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / AcOH; NaCNBH₃ / 2 h / 25 °C

2: 93 percent / tetrahydrofuran / 1.5 h / Heating

3: 72 percent / POBr₃; imidazole; anisole / 25 h / 25 °C

With 1H-imidazole; sodium cyanoborohydride; acetic acid; methoxybenzene; phosphorus(V) oxybromide; In tetrahydrofuran;
DOI:10.1021/ja064228j