4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

Base Information

Chemical Name:4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene
CAS No.:1160924-21-9
Molecular Formula:C₁₇H₂₅BrN₂O₃
Molecular Weight:385.301
Hs Code.:

Synonyms:4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

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Chemical Property of 4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

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Technology Process of 4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

There total 6 articles about 4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 43192-33-2
4-bromo-2-methoxybenzaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1160924-21-9
4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

Guidance literature:: 4-bromo-2-methoxybenzaldehyde; 1-t-Butoxycarbonylpiperazine; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield: 54.3%

: 1464157-34-3
4-bromo-2-methoxyphenyl-(4-tert-butoxycarbonylpiperazine-1-yl)methanone

: 1160924-21-9
4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

Guidance literature:: 4-bromo-2-methoxyphenyl-(4-tert-butoxycarbonylpiperazine-1-yl)methanone; With borane-THF; In tetrahydrofuran; at 0 - 60 ℃; for 14h; Inert atmosphere; Reflux;

In tetrahydrofuran; isopropyl alcohol; toluene; at 80 ℃; for 8h; Inert atmosphere;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1160924-21-9
4-bromo-2-methoxy-1-(4-tert-butoxycarbonylpiperazine-1-yl)methylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 14 h / 0 - 60 °C / Inert atmosphere; Reflux

3.2: 8 h / 80 °C / Inert atmosphere

With borane-THF; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;