Technology Process of [(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanesulfonic acid trifluoroacetate salt
There total 6 articles about [(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanesulfonic acid trifluoroacetate salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R,5R)-8-(bromomethyl)-3-butyl-3-ethyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine-1,1-dioxide;
With
sodium sulfite;
In
1,4-dioxane; water;
Reflux;
trifluoroacetic acid;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C
1.2: Cooling with ice
2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
3.1: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 0.25 h
3.2: 70 °C
4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 - 20 °C / Inert atmosphere
5.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C
6.1: sodium sulfite / 1,4-dioxane; water / Reflux
With
pyridine; 1H-imidazole; hydrogenchloride; aluminum (III) chloride; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; sodium sulfite;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
2.1: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 0.25 h
2.2: 70 °C
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C
5.1: sodium sulfite / 1,4-dioxane; water / Reflux
With
pyridine; 1H-imidazole; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; sodium sulfite;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
