2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

Base Information

Chemical Name:2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline
CAS No.:129265-24-3
Molecular Formula:C₃₅H₄₅N₃O₆SSi
Molecular Weight:663.91
Hs Code.:

Synonyms:2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

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Chemical Property of 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

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Technology Process of 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

There total 14 articles about 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66531-21-3
1-<(2,2,2-trichloroethoxy)carbonyl>-1,2-dihydropyridine

: 129265-24-3
2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1: 40 percent / 132 h / 110 °C

2: 81 percent / 10percent aq. NaOH / tetrahydrofuran / 5 h / 25 °C

3: 90 percent / p-toluenesulfonic acid / ethanol / 24 h / 70 °C

4: 99 percent / zinc / ethanol / 1 h / Heating

5: 60 percent / sodium iodide, diisopropylethylamine / dimethylsulfoxide / 120 h / 25 °C

6: 1.) n-butyllithium / 1.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C, 4 h, 2.) 25 deg C, 24 h

7: 2.) 25percent aq. acetic acid / 1.) acetonitrile, reflux, 6.5 d, 2.) tetrahydrofuran, 24 deg C, 3 h

8: 64 percent / triethylaluminum / hexane; benzene / 7 h / 25 °C

9: 1.) BH₃-THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 20 h, 2.) -10 deg C, 20 min

10: 1.) n-butyllithium / 1.) tetrahydrofuran, hexane, -78 deg C, 1 h, 2.)a) -78 deg C, 1 h, b) -40 deg C, 3 h

With sodium hydroxide; n-butyllithium; borane-THF; dihydrogen peroxide; triethylaluminum; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; zinc; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide; benzene;

Reference yield:

: 129265-11-8
7,7-diethoxyisoquinuclidene

: 129265-24-3
2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / sodium iodide, diisopropylethylamine / dimethylsulfoxide / 120 h / 25 °C

2: 1.) n-butyllithium / 1.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C, 4 h, 2.) 25 deg C, 24 h

3: 2.) 25percent aq. acetic acid / 1.) acetonitrile, reflux, 6.5 d, 2.) tetrahydrofuran, 24 deg C, 3 h

4: 64 percent / triethylaluminum / hexane; benzene / 7 h / 25 °C

5: 1.) BH₃-THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 20 h, 2.) -10 deg C, 20 min

6: 1.) n-butyllithium / 1.) tetrahydrofuran, hexane, -78 deg C, 1 h, 2.)a) -78 deg C, 1 h, b) -40 deg C, 3 h

With sodium hydroxide; n-butyllithium; borane-THF; dihydrogen peroxide; triethylaluminum; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; In hexane; dimethyl sulfoxide; benzene;

Reference yield:

: 129265-09-4
1-<(2,2,2-trichloroethoxy)carbonyl>-7-ketoisoquinuclidene

: 129265-24-3
2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / p-toluenesulfonic acid / ethanol / 24 h / 70 °C

2: 99 percent / zinc / ethanol / 1 h / Heating

3: 60 percent / sodium iodide, diisopropylethylamine / dimethylsulfoxide / 120 h / 25 °C

4: 1.) n-butyllithium / 1.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C, 4 h, 2.) 25 deg C, 24 h

5: 2.) 25percent aq. acetic acid / 1.) acetonitrile, reflux, 6.5 d, 2.) tetrahydrofuran, 24 deg C, 3 h

6: 64 percent / triethylaluminum / hexane; benzene / 7 h / 25 °C

7: 1.) BH₃-THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 20 h, 2.) -10 deg C, 20 min

8: 1.) n-butyllithium / 1.) tetrahydrofuran, hexane, -78 deg C, 1 h, 2.)a) -78 deg C, 1 h, b) -40 deg C, 3 h

With sodium hydroxide; n-butyllithium; borane-THF; dihydrogen peroxide; triethylaluminum; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; zinc; In ethanol; hexane; dimethyl sulfoxide; benzene;