methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

Base Information

• Chemical Name: methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate
• CAS No.: 220324-59-4
• Molecular Formula: C₂₀H₂₂N₂O₅S
• Molecular Weight: 402.471
• Mol file: 220324-59-4.mol

Synonyms:methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

Chemical Property of methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

There total 3 articles about methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 2-(3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate (103809-91-2) + benzenesulfonyl chloride (1939-99-7) → methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate (220324-59-4)

Guidance literature:

With triethylamine; In acetonitrile;

DOI:10.1016/S0960-894X(99)00417-5

Reference yield:

methyl 2-(3-(((9H-9-fluorenylmethoxy)carbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate (220324-57-2) → methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate (220324-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₂NH / CH₂Cl₂ / 20 °C

2: 68 percent / Et₃N / acetonitrile

With diethylamine; triethylamine; In dichloromethane; acetonitrile; 1: Deprotection / 2: Sulfonation;

DOI:10.1016/S0960-894X(99)00417-5

Reference yield:

[3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid (204322-78-1) → methyl 2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate (220324-59-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / CDI / acetonitrile / 20 °C

2: 84 percent / Et₂NH / CH₂Cl₂ / 20 °C

3: 68 percent / Et₃N / acetonitrile

With diethylamine; triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; acetonitrile; 1: Esterification / 2: Deprotection / 3: Sulfonation;

DOI:10.1016/S0960-894X(99)00417-5

upstream raw materials:

methyl 2-(3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

benzenesulfonyl chloride

methyl 2-(3-(((9H-9-fluorenylmethoxy)carbonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate

[3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid

Downstream raw materials:

2-(3-((benzylsulfonyl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic acid