Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI)

Base Information

Chemical Name:Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI)
CAS No.:184032-78-8
Molecular Formula:C₁₂H₂₁NO
Molecular Weight:195.305
Hs Code.:
Mol file:184032-78-8.mol

Synonyms:Cyclopentanol,1-(octahydrocyclopenta[b]pyrrol-2-yl)-,[2R-(2-alpha-,3a-bta-,6a-bta-)]-(9CI);Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI)

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Chemical Property of Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI)

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Technology Process of Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI)

There total 3 articles about Cyclopentanol, 1-(octahydrocyclopenta[b]pyrrol-2-yl)-, [2R-(2-alpha-,3a-ba-,6a-ba-)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 184032-80-2
(2R,3aR,6aR)-2-(1-Hydroxy-cyclopentyl)-hexahydro-cyclopenta[b]pyrrole-1-carboxylic acid tert-butyl ester

: 184032-78-8,189273-19-6
1-((1R,3R,5R)-2-Azabicyclo[3.3.0]octan-3-yl)cyclopentanol

Guidance literature:: With hydrogenchloride; In acetic acid; for 3h; Ambient temperature;
DOI:10.1080/00397919608003849

Reference yield:

: 184032-77-7
(2R,3aR,6aR)-Hexahydro-cyclopenta[b]pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 184032-78-8,189273-19-6
1-((1R,3R,5R)-2-Azabicyclo[3.3.0]octan-3-yl)cyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 58.5 percent / Mg / tetrahydrofuran / 0 deg C to 5 deg C, 30 min, 5 deg C to rt, 16 h

2: 89 percent / aq. HCl / acetic acid / 3 h / Ambient temperature

With hydrogenchloride; magnesium; In tetrahydrofuran; acetic acid;
DOI:10.1080/00397919608003849

Reference yield:

: (2R,3aR,6aR)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester; hydrochloride

: 184032-78-8,189273-19-6
1-((1R,3R,5R)-2-Azabicyclo[3.3.0]octan-3-yl)cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / tetrahydrofuran / 0 deg C, 45 min, 0 deg C to rt, 18 h

2: 58.5 percent / Mg / tetrahydrofuran / 0 deg C to 5 deg C, 30 min, 5 deg C to rt, 16 h

3: 89 percent / aq. HCl / acetic acid / 3 h / Ambient temperature

With hydrogenchloride; magnesium; triethylamine; In tetrahydrofuran; acetic acid;
DOI:10.1080/00397919608003849