4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

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Chemical Name:4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine
CAS No.:1293938-92-7
Molecular Formula:C₂₂H₂₅N₇O₂
Molecular Weight:419.486
Hs Code.:

Synonyms:4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

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Chemical Property of 4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

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Technology Process of 4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

There total 5 articles about 4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1293940-61-0
(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl(2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methanone

: 31058-83-0
6-chloro-N,N-dimethylpyrimidin-4-amine

: 1293938-92-7
4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 200 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1293940-99-4
tert-butyl (1R,6S)-8-(1(S)-phenylethyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate

: 1293938-92-7
4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; acetic acid / 20% palladium(II) hydroxide on carbon / ethanol / 16 h / 50 °C / 75007.5 Torr

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 14 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 200 °C / Microwave irradiation

With hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20% palladium(II) hydroxide on carbon; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 370881-96-2
(1S,6R)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester

: 1293938-92-7
4-(dimethylamino)-6-[8-{[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 14 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 200 °C / Microwave irradiation

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;