3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

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Chemical Name:3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester
CAS No.:334799-11-0
Molecular Formula:C₂₅H₂₉NO₆
Molecular Weight:439.508
Hs Code.:

Synonyms:3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

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Chemical Property of 3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

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Technology Process of 3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

There total 1 articles about 3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 61637-66-9
5-formyl-2-iodo-4-(2-methoxycarbonylethyl)-3-methylpyrrole

: 149885-09-6
(2S,3S)-3-((R)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoic acid

: 334799-11-0
3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; In triethylamine; acetonitrile; for 18h; Heating;
DOI:10.1021/ol006977q

Reference yield:

: 334799-11-0
3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

: 3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-2-hydroxy-4-methyl-5-oxo-pyrrolidin-2-ylmethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

Guidance literature:: With ammonia; In tetrahydrofuran; at -33 ℃; for 1.5h;
DOI:10.1021/ol006977q

Reference yield:

: 334799-11-0
3-{5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-dihydro-furan-(2Z)-ylidenemethyl]-2-formyl-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

: 334799-12-1
C₄₁H₄₅ClN₄O₆Se

Guidance literature:: Multi-step reaction with 3 steps

1: NH₃ / tetrahydrofuran / 1.5 h / -33 °C

2: 171 mg / aq. HCl / CHCl₃ / 24 h / 20 °C

3: 72 percent / HCl / methanol; diethyl ether; CH₂Cl₂ / 30 h / 20 °C

With hydrogenchloride; ammonia; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform;
DOI:10.1021/ol006977q