C₂₁H₂₆ClNO₃

Base Information

• Chemical Name: C₂₁H₂₆ClNO₃
• CAS No.: 1002331-29-4
• Molecular Formula: C₂₁H₂₆ClNO₃
• Molecular Weight: 375.895
• Mol file: 1002331-29-4.mol

Synonyms:C₂₁H₂₆ClNO₃

Chemical Property of C₂₁H₂₆ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆ClNO₃

There total 6 articles about C₂₁H₂₆ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C21H24ClNO4 (945989-84-4) → C21H26ClNO3 (1002331-29-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 40 ℃; for 18h;

DOI:10.1016/j.bmcl.2007.04.056

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → C21H26ClNO3 (1002331-29-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / PPTS / CH₂Cl₂ / 12 h

2: 100 percent / Cs₂CO₃ / acetone / 4 h / 40 °C

3: 100 percent / aq. LiOH / tetrahydrofuran / 18 h / 40 °C

4: CDI / dimethylformamide / 60 °C

5: 70 percent / LiAlH₄ / tetrahydrofuran / 18 h / 40 °C

With lithium hydroxide; lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; caesium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2007.04.056

Reference yield:

C20H21ClO5 (945989-82-2) → C21H26ClNO3 (1002331-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / aq. LiOH / tetrahydrofuran / 18 h / 40 °C

2: CDI / dimethylformamide / 60 °C

3: 70 percent / LiAlH₄ / tetrahydrofuran / 18 h / 40 °C

With lithium hydroxide; lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.04.056

upstream raw materials:

C₂₁H₂₄ClNO₄

3,4-dihydro-2H-pyran

C₂₀H₂₁ClO₅

methyl 2-hydroxy-5-(tetrahydropyranyloxy)benzoate

Downstream raw materials:

C₁₆H₁₈ClNO₂