4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate

Base Information

• Chemical Name: 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate
• CAS No.: 736969-67-8
• Molecular Formula: C₃₁H₃₂Cl₃NO₇
• Molecular Weight: 636.957
• Mol file: 736969-67-8.mol

Synonyms:4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate

Chemical Property of 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate

There total 9 articles about 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-O-acetyl-2,3,6-tri-O-benzyl-β-D-glucopyranoside (84218-71-3,114079-12-8,127874-07-1,127875-24-5,127875-31-4,127875-37-0) + trichloroacetonitrile (545-06-2) → 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate (736969-67-8)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 23h;

DOI:10.1016/S0008-6215(99)00131-7

Reference yield: 72.0%

4-O-acetyl-2,3,6-tri-O-benzyl-β-D-glucopyranoside (84218-71-3,114079-12-8,127874-07-1,127875-24-5,127875-31-4,127875-37-0) → 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate (736969-67-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichloroacetonitrile; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 72.0%

(2R,3R,4R)-4-benzyloxy-N-benzyloxycarbonyl-2-benzyloxymethyl-pyrrolidin-3-yl 4-O-acetyl-2,3,6-tri-O-benzyl-α-D-glucopyranoside + trichloroacetonitrile (545-06-2) → 4-O-acetyl-2,3,6-tri-O-benzyl-α,β-D-glucopyranosyl trichloroimidate (736969-67-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

4-O-acetyl-2,3,6-tri-O-benzyl-β-D-glucopyranoside

trichloroacetonitrile

(2R,3R,4S,5R,6S)-4,5-Bis-benzyloxy-2-benzyloxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3-ol

2,3,6-tri-O-benzyl-D-glucopyranoside

Downstream raw materials:

(2R,3R,4R)-4-Benzyloxy-N-benzyloxycarbonyl-2-benzyloxymethyl-pyrrolidin-3-yl 4-O-acetyl-2,3,6-tri-O-benzyl-α-D-glucopyranoside