(S)-(+)-N-(Boc)-2-methylpiperidine

Base Information

• Chemical Name: (S)-(+)-N-(Boc)-2-methylpiperidine
• CAS No.: 183903-99-3
• Molecular Formula: C11H21 N O2
• Molecular Weight: 199.29
• Hs Code.: 2933399990
• European Community (EC) Number: 623-205-2
• DSSTox Substance ID: DTXSID90452135
• Nikkaji Number: J792.963C
• Wikidata: Q76416459
• Mol file: 183903-99-3.mol

Synonyms:183903-99-3;(S)-(+)-N-(Boc)-2-methylpiperidine;(S)-(+)-N-tBOC-2-Methylpiperidine;TERT-BUTYL (2S)-2-METHYLPIPERIDINE-1-CARBOXYLATE;(S)-tert-Butyl 2-methylpiperidine-1-carboxylate;SCHEMBL7002987;N-BOC-6(S)-methyl-piperidine;DTXSID90452135;DHJKRRZIUOQEFW-VIFPVBQESA-N;(S)-(+)-N-Boc-2-methylpiperidine;MFCD06799025;AKOS025294774;AC-15353;CS-0079153;(S)-N-tert-butoxycarbonyl-2-methylpiperidine;t-Butyl (S)-2-methylpiperidine-1-carboxylate;(S)-(+)-N-(Boc)-2-methylpiperidine, 98%;E89317;J-011783;(2S)-1-(tert-Butoxycarbonyl)-2beta-methylpiperidine

Chemical Property of (S)-(+)-N-(Boc)-2-methylpiperidine

Chemical Property:

• Vapor Pressure: 0.0167mmHg at 25°C
• Refractive Index: n20/D 1.453(lit.)
• Boiling Point: 54-56 °C0.05 mm Hg(lit.)
• Flash Point: 215 °F
• PSA: 29.54000
• Density: 0.937 g/mL at 25 °C(lit.)
• LogP: 2.73380
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.157228913
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

95-99% ^*data from raw suppliers

(S)-(+)-N-(Boc)-2-methylpiperidine 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CCCCN1C(=O)OC(C)(C)C
• Isomeric SMILES: C[C@H]1CCCCN1C(=O)OC(C)(C)C

Technology Process of (S)-(+)-N-(Boc)-2-methylpiperidine

There total 12 articles about (S)-(+)-N-(Boc)-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-2-hydroxy-2-phenylacetate (S)-2-methylpiperidinium → (+)-(S)-N-tert-butoxycarbonyl-2-methylpiperidine (183903-99-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1080/00397919908086162

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-methyl-piperidine; Lg-hydrogentartrate (36702-48-4,36702-49-5) → (+)-(S)-N-tert-butoxycarbonyl-2-methylpiperidine (183903-99-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja962542f

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-methylpiperidine (3197-42-0) → (+)-(S)-N-tert-butoxycarbonyl-2-methylpiperidine (183903-99-3)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1021/ol047676+ DOI:10.1016/j.tet.2005.09.050

upstream raw materials:

di-tert-butyl dicarbonate

(S)-2-methyl-piperidine; L_g-hydrogentartrate

(S)-2-Methyl-1-[(R)-1-phenylethyl]piperidine

(S)-2-methylpiperidine

Downstream raw materials:

1,1-dimethyl<(2R,6S)-2-<(1E,3Z,5S)-5-hydroxy-1,3-hexadienyl>-6-methyl-1-piperidine>carboxylate

(2S,6S)-2-[(1E,3Z)-(S)-5-((E)-3-Cyclohex-1-enyl-acryloyloxy)-hexa-1,3-dienyl]-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

Himandravine

himbeline