(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide
CAS No.:1369852-94-7
Molecular Formula:C₂₂H₂₁F₃N₂O₂
Molecular Weight:402.416
Hs Code.:

Synonyms:(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

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Chemical Property of (E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

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Technology Process of (E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

There total 5 articles about (E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1369852-81-2
N-[2-(1-benzyl-2-iodo-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

: 82994-41-0,81925-29-3,74141-12-1,74141-13-2
(E)-3-(tri-n-butylstannyl)-2-propen-1-ol

: 1369852-94-7
(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In N,N-dimethyl-formamide; at 75 ℃; for 16h; Inert atmosphere;
DOI:10.1055/s-0031-1289656

Reference yield:

: 1369852-61-8
N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

: 1369852-94-7
(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; lithium chloride; In diethyl ether; hexane; N,N-dimethyl-formamide; 2.1: Stille coupling;
DOI:10.1055/s-0031-1289656

Reference yield:

: 4307-98-6
N-benzyltryptamine

: 1369852-94-7
(E)-N-{2-[1-benzyl-2-(3-hydroxyprop-1-enyl)-1H-indol-3-yl]ethyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; lithium chloride; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Stille coupling;
DOI:10.1055/s-0031-1289656