2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide

Base Information

• Chemical Name: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide
• CAS No.: 912342-00-8
• Molecular Formula: C₁₂H₁₂F₃NO₃
• Molecular Weight: 275.227
• Mol file: 912342-00-8.mol

Synonyms:2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide

Chemical Property of 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide

There total 3 articles about 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methyllithium (917-54-4) + 4-(Methoxymethoxy)-1-benzonitrile (161196-99-2) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide (912342-00-8)

Guidance literature:

With lithium bromide;

DOI:10.1016/j.tetlet.2006.06.135

Reference yield: 26.0%

1-(4-methoxymethoxy-phenyl)-ethanone oxime (912341-94-7) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide (912342-00-8)

Guidance literature:

With iron; trifluoroacetic acid; In ethyl acetate; at 65 ℃;

DOI:10.1016/j.tetlet.2006.06.135

Reference yield:

1-[4-(methoxymethoxy)phenyl]-1-ethanone (85699-00-9) → 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-vinyl]-acetamide (912342-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / TFA; Fe / ethyl acetate / 65 °C

With iron; trifluoroacetic acid; In ethyl acetate;

DOI:10.1016/j.tetlet.2006.06.135

upstream raw materials:

1-(4-methoxymethoxy-phenyl)-ethanone oxime

trifluoroacetic anhydride

methyllithium

4-(Methoxymethoxy)-1-benzonitrile