tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate
CAS No.:1309767-12-1
Molecular Formula:C₂₉H₄₁N₃O₈
Molecular Weight:559.66
Hs Code.:

Synonyms:tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

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Chemical Property of tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

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Technology Process of tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

There total 7 articles about tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1029126-05-3
2-amino-4-(3-benzyloxycarbonyl-propyl)-imidazole-1-carboxylic acid tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1309767-12-1
tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1039/c1cc10691k

Reference yield:

: 108-55-4
glutaric anhydride,

: 1309767-12-1
tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 48 h / 0 - 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.45 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / 0 °C

2.3: 0.5 h / 0 °C

3.1: N,N-dimethyl-formamide / 120 h / 20 °C

4.1: dmap / tetrahydrofuran / 48 h / 20 °C

With dmap; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1cc10691k

Reference yield:

: 54322-10-0
glutaric acid monobenzyl ester

: 1309767-12-1
tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.45 h / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / 0 °C

1.3: 0.5 h / 0 °C

2.1: N,N-dimethyl-formamide / 120 h / 20 °C

3.1: dmap / tetrahydrofuran / 48 h / 20 °C

With dmap; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1cc10691k