(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

Base Information

Chemical Name:(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide
CAS No.:1599463-13-4
Molecular Formula:C₁₂H₁₄F₃NO₃S
Molecular Weight:309.309
Hs Code.:

Synonyms:(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

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Chemical Property of (S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

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Technology Process of (S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

There total 3 articles about (S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1599463-36-1
(Z)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)vinyl)acetamide

: 1599463-13-4
(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

Guidance literature:: With C₂₄H₄₄P₂Rh⁽¹⁺⁾*BF₄^(1-); hydrogen; In methanol; at 25 ℃; for 12h; under 38002.6 Torr; enantioselective reaction;
DOI:10.1021/cs500261k

Reference yield:

: 2967-66-0
methyl 4-(trifluoromethyl)benzoate

: 1599463-13-4
(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 1.5 h / 50 - 60 °C / Inert atmosphere

2.1: titanium(IV) isopropylate; ammonia / methanol; toluene / 24 h / 20 °C / Inert atmosphere; Sealed tube; Cooling with ice

2.2: 20 °C / Inert atmosphere; Cooling with ice

3.1: nickel diacetate; (S)-binapine; hydrogen / methanol; 2,2,2-trifluoroethanol / 12 h / 50 °C / 38002.6 Torr / Autoclave

With titanium(IV) isopropylate; (S)-binapine; potassium tert-butylate; ammonia; hydrogen; nickel diacetate; In methanol; 2,2,2-trifluoroethanol; dimethyl sulfoxide; toluene;
DOI:10.1021/acs.orglett.8b02579

Reference yield:

: C₁₀H₁₀F₃NO₂S

: 1599463-13-4
(S)-N-(2-(methylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: C₂₄H₄₄P₂Rh⁽¹⁺⁾*BF₄^(1-); hydrogen / methanol / 12 h / 25 °C / 38002.6 Torr

With pyridine; C₂₄H₄₄P₂Rh⁽¹⁺⁾*BF₄^(1-); hydrogen; In methanol;
DOI:10.1021/cs500261k