(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

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Chemical Name:(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate
CAS No.:1422052-38-7
Molecular Formula:C₄₀H₃₈F₂N₆O₂
Molecular Weight:672.778
Hs Code.:

Synonyms:(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

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Chemical Property of (+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

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Technology Process of (+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

There total 11 articles about (+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383446-11-4
5-fluoro-3-(4,4,5,5-tetramethyl-1.3.2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3.4-b] pyridine

: 1422052-37-6
(+/-)-ethyl 3-(2-chloro-5-fluoropyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

: 1422052-38-7
(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

Guidance literature:: 5-fluoro-3-(4,4,5,5-tetramethyl-1.3.2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3.4-b] pyridine; (+/-)-ethyl 3-(2-chloro-5-fluoropyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate; With potassium phosphate; In 2-methyltetrahydrofuran; water; for 0.5h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; water; at 135 ℃; for 1h; Inert atmosphere;

Reference yield:

: 38186-88-8
2-chloro-5-fluoronicotinic acid

: 1422052-38-7
(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 0 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C

3.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux

4.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

6.2: 1.5 h / 100 °C

7.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.5 h / Inert atmosphere

7.2: 1 h / 135 °C / Inert atmosphere

With potassium phosphate; tert.-butylnitrite; oxalyl dichloride; Bromoform; potassium acetate; potassium carbonate; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1034667-22-5
5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine

: 1422052-38-7
(+/-)-ethyl 3-(5-fluoro-2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ylamino)-3-(1-methylcyclopentyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

3.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

3.2: 1.5 h / 100 °C

4.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.5 h / Inert atmosphere

4.2: 1 h / 135 °C / Inert atmosphere

With potassium phosphate; tert.-butylnitrite; Bromoform; potassium acetate; potassium carbonate; In 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;