Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate

Base Information

• Chemical Name: Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate
• CAS No.: 82967-44-0
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 82967-44-0.mol

Synonyms:Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate

Chemical Property of Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate

There total 4 articles about Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Methyl 8-(N-methyl)aminomethylquinoline-5-carboxylate (82967-42-8) + benzyl chloroformate (501-53-1,94274-21-2) → Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate (82967-44-0)

Guidance literature:

With magnesium oxide; In chloroform; water; 1.) 30 min, ice cooling, 2.) 1 h, 20 deg C_.;

DOI:10.1007/BF00506150

Reference yield:

8-methylquinoline-5-carbonitrile (74316-57-7) → Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate (82967-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / Conc_. sulfuric acid / 48 h / Heating

2: 70 percent / N-Bromosuccimide / Benzoyl peroxide / CCl₄ / Heating; Irradiation

3: 45 percent / methanol / 1.5 h

4: 79 percent / Magnesium oxide / CHCl₃; H₂O / 1.) 30 min, ice cooling, 2.) 1 h, 20 deg C_.

With N-Bromosuccinimide; magnesium oxide; sulfuric acid; dibenzoyl peroxide; In methanol; tetrachloromethane; chloroform; water;

DOI:10.1007/BF00506150

Reference yield:

Methyl 8-methylquinoline-5-carboxylate (82967-38-2) → Methyl 8-(N-methyl-N-carbobenzoxy)methylaminoquinoline-5-carboxylate (82967-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / N-Bromosuccimide / Benzoyl peroxide / CCl₄ / Heating; Irradiation

2: 45 percent / methanol / 1.5 h

3: 79 percent / Magnesium oxide / CHCl₃; H₂O / 1.) 30 min, ice cooling, 2.) 1 h, 20 deg C_.

With N-Bromosuccinimide; magnesium oxide; dibenzoyl peroxide; In methanol; tetrachloromethane; chloroform; water;

DOI:10.1007/BF00506150

upstream raw materials:

Methyl 8-(N-methyl)aminomethylquinoline-5-carboxylate

benzyl chloroformate

methyl 8-(bromo-methyl)quinoline-5-carboxylate

8-methylquinoline-5-carbonitrile