3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

Base Information

Chemical Name:3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol
CAS No.:1628058-58-1
Molecular Formula:C₁₁H₁₄O₂
Molecular Weight:178.231
Hs Code.:

Synonyms:3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

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Technology Process of 3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

There total 11 articles about 3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1628058-60-5
C₃₃H₄₆O₂Si₂

: 1628058-58-1
3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1002/ejoc.201402157

Reference yield:

: methyl 2-(4-hydroxybut-1-en-2-yl)benzoate

: 1628058-58-1
3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 - 0 ℃; for 4h;
DOI:10.1039/c6cc06356j

Reference yield:

: 1628058-56-9
1-(2-((tert-butyldiphenylsilyloxy)methyl)phenyl)propane-1,3-diol

: 1628058-58-1
3-(2-(hydroxymethyl)phenyl)but-3-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -78 - 20 °C

2.2: 2 h / 25 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C

3.2: 23 °C

4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 12 h / 20 °C

With pyridine; 1H-imidazole; oxalyl dichloride; hydrogen fluoride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1002/ejoc.201402157