4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Base Information

• Chemical Name: 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
• CAS No.: 1401226-60-5
• Molecular Formula: C₂₀H₁₄F₃N₃O₄
• Molecular Weight: 417.344

Synonyms:4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Chemical Property of 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Chemical Property:

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Technology Process of 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

There total 4 articles about 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(3-acetyl-4-allyloxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (1401226-59-2) → 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (1401226-60-5)

Guidance literature:

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm300281x

Reference yield:

4-bromo-2-(trifluoromethyl)benzonitrile (191165-13-6) → 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (1401226-60-5)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 3 h / 160 °C / Inert atmosphere

2: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 4 h / 20 °C / Inert atmosphere

With copper(I) oxide; boron dimethyl-trifluoro sulphide; triethylamine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1021/jm300281x

Reference yield:

5-phenyl-5-(2-propenyloxy)methylimidazolidine-2,4-dione (1215085-65-6) → 4-(3-acetyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (1401226-60-5)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 3 h / 160 °C / Inert atmosphere

2: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 4 h / 20 °C / Inert atmosphere

With copper(I) oxide; boron dimethyl-trifluoro sulphide; triethylamine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1021/jm300281x

upstream raw materials:

4-bromo-2-(trifluoromethyl)benzonitrile

5-phenyl-5-(2-propenyloxy)methylimidazolidine-2,4-dione

4-[2,5-dioxo-4-phenyl-4-[(2-propenyloxy)methyl]imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

4-(3-acetyl-4-allyloxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

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