(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Base Information

Chemical Name:(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne
CAS No.:263138-29-0
Molecular Formula:C₂₆H₃₆O₃Si
Molecular Weight:424.656
Hs Code.:

Synonyms:(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Suppliers and Price of (2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

There total 2 articles about (2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 107-30-2
chloromethyl methyl ether

: 220634-80-0
(2R,3S,4S)-1-(tert-butyldiphenylsilyloxy)-2,4-dimethyl-5-hexyn-3-ol

: 263138-29-0
(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 63h;
DOI:10.1021/jo991689x

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 263138-29-0
(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / PdCl₂(dppf)-CH₂Cl₂; indium(I) iodide / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h

2: 86 percent / i-Pr₂-NEt; Bu₄NI / CH₂Cl₂ / 63 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; indium iodide; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1: Addition / 2: Etherification;
DOI:10.1021/jo991689x

Reference yield: 43.0%

: 263138-27-8
(2R,3R,4R)-2,4-dimethyl-6-(4-methoxybenzyl)oxy-3-(methoxymethoxy)hexanal

: 263138-29-0
(2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne

: 263138-30-3
(2R,3S,4S,7R,8R,9R,10R)-3,9-bis(methoxymethoxy)-1-(tert-butyldiphenylsilyl)oxy-12-(4-methoxybenzyloxy)-2,3,8,10-tetramethyl-5-dodecyn-7-ol

: 263138-31-4
(2R,3S,4S,7S,8R,9R,10R)-3,9-bis(methoxymethoxy)-1-(tert-butyldiphenylsilyl)oxy-12-(4-methoxybenzyloxy)-2,4,8,10-tetramethyl-5-dodecyn-7-ol

Guidance literature:: (2R,3S,4S)-(tert-butyldiphenylsilyl)oxy-2,4-dimethyl-3-(methoxymethoxy)-5-hexyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃;

(2R,3R,4R)-2,4-dimethyl-6-(4-methoxybenzyl)oxy-3-(methoxymethoxy)hexanal; With lithium bromide; In tetrahydrofuran; hexane; at -35 ℃; for 1h; Further stages.;
DOI:10.1021/jo991689x