(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

Base Information

Chemical Name:(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid
CAS No.:945979-01-1
Molecular Formula:C₄₅H₆₇N₃O₂
Molecular Weight:682.046
Hs Code.:

Synonyms:(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

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Chemical Property of (2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

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Technology Process of (2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

There total 10 articles about (2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1569300-03-3
methyl (2S,3R,Z)-2-phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoate

: 945979-01-1
(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

Guidance literature:: With hydrogenchloride; In water; at 70 ℃; for 80h;
DOI:10.1021/ol500096r

Reference yield:

: methyl (3R,R_S)-2-phenyl-3-(N-tert-butylsulfinamido)-16-(pyridin-3′-yl)hexadec-13-enoate

: 945979-01-1
(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / methanol / 8 h / 0 °C

2: hydrogenchloride / methanol / 2 h / 20 °C

3: 1,2-dichloro-ethane / 0.08 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h / 20 °C

5: hydrogenchloride / water / 80 h / 70 °C

With hydrogenchloride; sodium; sodium tris(acetoxy)borohydride; acetic acid; In methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/ol500096r

Reference yield:

: 133835-22-0
(Z)-14-(pyridin-3′-yl)tetradec-11-enal

: 945979-01-1
(2S,3R,Z)-2-Phenyl-3-{N-[13′′-(pyridin-3′′′-yl)tridecyl]amino}-16-(pyridin-3′-yl)hexadec-13-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 16 h / 20 °C

2.1: methylmagnesium bromide; magnesium bromide / diethyl ether; tetrahydrofuran / 1 h / -78 °C

2.2: 6 h / -78 °C

3.1: hydrogenchloride / methanol / 2 h / 20 °C

4.1: 1,2-dichloro-ethane / 0.08 h / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h / 20 °C

6.1: hydrogenchloride / water / 80 h / 70 °C

With hydrogenchloride; methylmagnesium bromide; pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; magnesium sulfate; acetic acid; magnesium bromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/ol500096r