4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester

Base Information

• Chemical Name: 4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
• CAS No.: 183483-15-0
• Molecular Formula: C₂₂H₂₃ClN₂O₃
• Molecular Weight: 398.889
• Mol file: 183483-15-0.mol

Synonyms:3-Hydroxy Loratadine;4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester

Chemical Property of 4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester

Chemical Property:

• Melting Point: 138-152?C
• Refractive Index: 1.632
• PSA: 62.66000
• LogP: 4.53130
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3-HydroxyLoratadine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate for the preparation of 3-Hydroxy Desloratadine An intermediate for the preparation of 3-Hydroxy Desloratadine.

Technology Process of 4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester

There total 1 articles about 4-(8-Chloro-5,6-dihydro-3-hydroxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

loratadine (79794-75-5) → 3-hydroxyloratadine (183483-15-0) + ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-3,5-dihydroxypiperidine-1-carboxylate + ethyl (Z)-4-(8-chloro-3-hydroxy-5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate + ethyl (E)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-3-hydroxypiperidine-1-carboxylate + ethyl (E)-4-(8-chloro-5-hydroxy-5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate + ethyl (E)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate + ethyl (E)-4-(8-chloro-3-hydroxy-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:

With cytochrome P₄₅₀ from Bacillus megaterium CYP₁₀₂A₁ variant MCYP₀₀₁₂; In dimethyl sulfoxide; at 30 ℃; for 12h; pH=8; Enzymatic reaction;

DOI:10.1021/acs.jmedchem.0c00483

upstream raw materials:

loratadine

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