methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate

Base Information

• Chemical Name: methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate
• CAS No.: 131489-55-9
• Molecular Formula: C₁₂H₁₃NO₇S
• Molecular Weight: 315.304
• Mol file: 131489-55-9.mol

Synonyms:methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate

Chemical Property of methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate

There total 2 articles about methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-nitrobenzenesulfonyl peroxide (6209-72-9) + 2-methyl-1-trimethylsiloxy-1-methoxy-1,3-butadiene (75436-68-9) → methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate (131489-55-9)

Guidance literature:

With zinc(II) chloride; In ethyl acetate; at -78 ℃;

DOI:10.1021/jo00003a022

Reference yield:

methyl 2-methyl-3-butenoate (51747-33-2) → methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate (131489-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1. lithium diisopropylamide, HMPA / 1. THF, -78 deg C, 30 min 2. -> r.t., 1 h

2: 71 percent / ZnCl₂ / ethyl acetate / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; zinc(II) chloride; lithium diisopropyl amide; In ethyl acetate;

DOI:10.1021/jo00003a022

Reference yield: 88.0%

methyl 2-methyl-4-<<(p-nitrophenyl)sulfonyl>oxy>-2-butenoate (131489-55-9) + benzyl-methyl-amine (103-67-3) → methyl 2-methyl-4-(N-methyl-N-benzylamino)-2-butenoate (131489-63-9)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1021/jo00003a022

upstream raw materials:

4-nitrobenzenesulfonyl peroxide

2-methyl-1-trimethylsiloxy-1-methoxy-1,3-butadiene

methyl 2-methyl-3-butenoate

Downstream raw materials:

methyl 2-methyl-4-(N-methyl-N-benzylamino)-2-butenoate