N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester

Base Information

• Chemical Name: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester
• CAS No.: 1093115-84-4
• Molecular Formula: C₇₄H₈₂N₄O₁₅
• Molecular Weight: 1267.48
• Mol file: 1093115-84-4.mol

Synonyms:N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester

Chemical Property of N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester

There total 2 articles about N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C51H59N3O10 + Fmoc-Asp-O-t-Bu (129460-09-9,134098-70-7) → Nα-(9-fluorenylmethoxycarbonyl)-Nγ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester (1093115-84-4)

Guidance literature:

Fmoc-Asp-O-t-Bu; With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 1h;

C₅₁H₅₉N₃O₁₀; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃;

DOI:10.1021/jm801577r

Reference yield:

C51H59N3O10 + FmocAsp(OBt)OBut (383912-99-0) → Nα-(9-fluorenylmethoxycarbonyl)-Nγ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester (1093115-84-4)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.carres.2008.08.024

Reference yield: 96.0%

Nα-(9-fluorenylmethoxycarbonyl)-Nγ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester (1093115-84-4) → Nα-(9-fluorenylmethoxycarbonyl)-Nγ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine (1019849-43-4)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1016/j.carres.2008.08.024

upstream raw materials:

FmocAsp(OBt)OBu^t

Fmoc-Asp-O-t-Bu

Downstream raw materials:

N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine